A Robust Quantum Random Access Memory

A "bucket brigade" architecture for a quantum random memory of $N=2^n$ memory cells needs $n(n+5)/2$ times of quantum manipulation on control circuit nodes per memory call. Here we propose a scheme, in which only average $n/2$ times manipulation is required to accomplish a memory call. This scheme may significantly decrease the time spent on a memory call and the average overall error rate per memory call. A physical implementation scheme for storing an arbitrary state in a selected memory cell followed by reading it out is discussed.Comment: 5 pages, 3 figure

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.

The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinically due to high toxicity and poor efficacy. In this study, we report the identification of a chalcone analogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and act synergistically with known LRAs such as prostratin and JQ1 to reverse latency. Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin T1 heterodimer that is part of the super elongation complex (SEC) used by the viral encoded Tat protein to activate HIV transcription. Amt-87 does so by promoting the phosphorylation of CDK9 at the T-loop, liberating P-TEFb from the inactive 7SK snRNP, and inducing the formation of the Tat-SEC complex at the viral promoter. Together, our data reveal chalcones as a promising category of compounds that should be further explored to identify effective LRAs for targeted reversal of HIV latency

Distributed entanglement induced by dissipative bosonic media

We describe a scheme with analytic result that allows to generate steady-state entanglement for two atoms over a dissipative bosonic medium. The resonant coupling between the mediating bosonic mode and cavity modes produces three collective atomic decay channels. This dissipative dynamics, together with the unitary process induced by classical microwave fields, drives the two atoms to the symmetric or asymmetric entangled steady state conditional upon the choice of the phases of the microwave fields. The effects on the steady-state entanglement of off-resonance mediating bosonic modes are analyzed. The entanglement can be obtained with high fidelity regardless of the initial state and there is a linear relation in the scaling of the fidelity with the cooperativity parameter. The fidelity is insensitive to the fluctuation of the Rabi frequencies of the classical driving fields.Comment: to appear in Europhysics Letter